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MacroGenics Plunges On Prostate Cancer ADC Safety Concerns

 
• By Andrew McConaghie

A more than 70% stock slide shows that investors are concerned about three as-yet unexplained deaths in a Phase II study of the US firm’s lead candidate.

• Source: Shutterstock

MacroGenics has seen its share price plummet after Phase II results of its antibody-drug conjugate (ADC) showed a worsening safety profile in metastatic castration-resistant prostate cancer patients, including three as-yet unexplained deaths.

The company’s NASDAQ-listed stock has doubled over the past 12 months, thanks to red-hot investor interest in the ADC field,...

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