With GLP-1-based drugs ramping up staggering sales in obesity, and similar compounds in the clinic posting ever more impressive data, it is a brave company that chooses to pursue a non-incretin for the disorder. Shionogi & Co. Ltd. has learned that lesson the hard way, today disclosing disappointing results with its monoacylglycerol acyltransferase 2 inhibitor, S-309309.
Leftfield Obesity Mechanism Hurts Shionogi
When it comes to weight loss drug development, the sensible move is to follow the pack.

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Pipeline Watch is a weekly snapshot of selected late-stage clinical trial events and approvals announced by pharmaceutical and biotech companies at medical and industry conferences, in financial and company presentations, and in company releases and statements.