Johnson & Johnson has evidence that the benefits of dual treatment with the firm’s EGFR/MET inhibitor Rybrevant (amivantamab) and EGFR inhibitor Lazcluze (lazertinib) improve over time from updated results from the Phase III MARIPOSA clinical trial of the two-drug combination versus AstraZeneca PLC’s standard-of-care EGFR inhibitor Tagrisso (osimertinib) in first-line non-small cell lung cancer (NSCLC) with EGFR mutations.
J&J’s Rybrevant/Lazcluze MARIPOSA Update Shows Greater Gains Over Tagrisso
Subcutaneous Rybrevant Data Reinforce Safety, Convenience
Survival and other benefits with J&J’s EGFR/MET inhibitor Rybrevant plus EGFR inhibitor Lazcluze relative to AstraZeneca’s Tagrisso in first-line EGFR-mutant NSCLC continued to improve at 31.1 months.

More from Clinical Trials
RemeGen is planning to complete enrolment in the global Phase III RemeMG study with telitacicept in generalized myasthenia gravis by the end of 2025 or early 2026. The Chinese firm has already sidelined two other global Phase III trials with the molecule to prioritize the indication.
The biotech is banking on itolizumab’s longer-term efficacy as well as unmet need in frontline acute graft-versus-host disease as it prepares to meet with the FDA.
The head of the Spanish medical dermatology specialist told Scrip that maintaining the status quo will only result in the continent’s life sciences sector slipping further behind the US and China.
With its exon 53-skipping candidate already showing promise in 24-week data, Wave now has 48-week data showing improvements in muscle health and functional outcomes.
More from R&D
The Danish firm is spending nearly $580m to repurchase up to 2.2 million shares
The Texas-based firm is giving up on the investigational Alzheimer’s therapy after a second Phase III failure left it with nowhere to go in the disease.
A decision from the FDA is due by 28 September.