Merck & Co. and Daiichi’s Phase II ADC Hit Raises Expectations

Ifinatamab deruxtecan, a potential first-in-class B7-H3-targeted conjugate, looks promising – but the real test is to come.    

Lungs

The Phase III trial of Merck & Co., Inc. and Daiichi Sankyo Co., Ltd.’s ifinatamab deruxtecan (I-DXd) in small-cell lung cancer (SCLC) will report in 2027, and following the recent misfire with another of the partners’ antibody-drug conjugates, patritumab deruxtecan, they need this one to hit.

Key Takeaways
  • Mid-stage data suggest Merck & Co and Daiichi Sankyo’s antibody-drug conjugate ifinatamab deruxtecan could be competitive in small-cell lung cancer.

Fortunately, Merck and Daiichi will be more sanguine about the 2027 readout following encouraging data from a Phase II trial...

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