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Merck & Co. and Daiichi’s Phase II ADC Hit Raises Expectations

 
• By Elizabeth Cairns

Ifinatamab deruxtecan, a potential first-in-class B7-H3-targeted conjugate, looks promising – but the real test is to come.    

Lungs

The Phase III trial of Merck & Co., Inc. and Daiichi Sankyo Co., Ltd.’s ifinatamab deruxtecan (I-DXd) in small-cell lung cancer (SCLC) will report in 2027, and following the recent misfire with another of the partners’ antibody-drug conjugates, patritumab deruxtecan, they need this one to hit.

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• By Dexter Jie Yan

Results from a China Phase III trial show the potential of RemeGen's fusion protein telitacicept in generalized myasthenia gravis. But study design differences make direct comparisons with argenx's FcRn inhibitor Vyvgart challenging.

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More from R&D

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UK Promises To ‘Turbo-Charge’ Clinical Trials As Tariff Threat Remains

 
• By Andrew McConaghie

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