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Fosun ALK/ROS1 Inhibitor Shows 1L Promise In Advanced NSCLC

 
• By Xu Hu

Interim results from the Phase III REMARK study presented at WCLC showed the Chinese company’s second-generation ALK/ROS1 inhibitor met its primary endpoint as a first-line therapy in ALK-positive advanced NSCLC.

lung cancer
Fosun's ALK/ROS1 inhibitor meets primary endpoint in Phase III for ALK+ advanced NSCLC • Source: Shutterstock

Shanghai Fosun Pharmaceutical (Group) Co., Ltd.’s SAF-189s (foritinib succinate), a second-generation ALK/ROS1 inhibitor being developed as a first-line therapy, has shown efficacy superior to crizotinib (Pfizer Inc.'s Xalkori) in a Phase III trial for ALK-positive, advanced non-small cell lung cancer (NSCLC).

Interim results from the REMARK study with the oral central nervous system (CNS)-penetrating molecule, which can cross the blood-brain barrier,...

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• By Aakash Babu

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