Boehringer, Bayer Kinase Inhibitors Offer Oral Option In HER2-Mutated Lung Cancer

Both Drugs In Phase III First-Line Trials

Boehringer presented Phase Ib results for zongertinib and Bayer presented Phase I/II results for BAY 2927088 in NSCLC with HER2 mutations – a rare cancer with ADC Enhertu as a major competitor – at the WCLC meeting.

3d Human lungs healthcare and medical abstract background
Zongertinib and BAY 2927088 are the most advanced HER2 TKIs for NSCLC • Source: Shutterstock

Boehringer Ingelheim GmbH presented Phase Ib results and Bayer AG reported Phase I/II data for their HER2 inhibitors at World Conference on Lung Cancer (WCLC) that showed greater response rates for their oral drugs in previously treated non-small cell lung cancer (NSCLC) with HER2 mutations than seen with the only approved therapy in this indication, the AstraZeneca PLC/Daiichi Sankyo Co., Ltd. HER2-directed ADC Enhertu (trastuzumab deruxtecan).

Key Takeaways
  • HER2 tyrosine kinase inhibitors from Boehringer Ingelheim and Bayer showed promising efficacy in Phase Ib and Phase I/II clinical trials with better response rates than seen with the HER2 ADC Enhertu in NSCLC.

However, the efficacy gains for Boehringer’s zongertinib and Bayer’s BAY 2927088 presented in a 9 September plenary session at the...

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