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Shattuck Shifts Gears After Lackluster CD47-Targeting Bispecific Results

 
• By Alaric DeArment

The biotech is cutting jobs and discontinuing development of its anti-CD47 bispecific for blood cancers and moving its focus to SL-325, which targets the TL1A-DR3 axis in autoimmune diseases.

• Source: Shutterstock

Shattuck Labs, Inc. is moving to focus its clinical efforts on autoimmune diseases with SL-325 after deciding to discontinue its hematology-oncology candidate, SL-172154, due to efficacy that did not reach a high enough bar for overall survival (OS) improvement. The decision marks a strategic shift for the company, which includes a 40% reduction in its workforce, but also yet another blow for the once-promising field of CD47-directed cancer immunotherapies.

The biotech said 1 October that it would discontinue development of SL-172154, a CD47xCD40L-directed bispecific antibody, in TP53-mutated acute myeloid leukemia (AML) and higher-risk myelodysplastic syndrome (MDS) and instead focus on SL-325, which targets DR3, with plans for initial clinical development in

Key Takeaways

  • Shattuck said it would discontinue its program to develop SL-172154, a CD47xCD40L-directed bispecific antibody for AML and MDS, after lower-than-expected survival numbers.

  • The company will shift its focus to SL-325, which targets the DR3, part of the TL1A-DR3 axis that has become increasingly popular as an autoimmune disease target

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