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Trial Of Kezar’s Only Active Drug Halted After Five Patients Die

 
• By Elizabeth Cairns

The FDA has placed zetomipzomib on clinical hold a year after Kezar decided to focus solely on the product.    

A man shows a thumb down. Gesture of disapproval and rejection. Bad assessment, harsh criticism, failure and defeat. Refusal to pass and cooperation. Bureaucratic obstacles. Contempt and condemnation

Retooling a company to focus on a single asset is a high-risk strategy, and one that is generally taken when few other choices present themselves. Having taken this step last year, Kezar Life Sciences, Inc. is almost totally dependent on zetomipzomib reaching a successful Phase IIb readout in lupus nephritis – but this is now in doubt following the deaths of five trial subjects.

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