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Singapore ADC Specialist Axcynsis Nets Novel Payload To Address Drug Resistance

 
• By Dexter Jie Yan

Axcynsis is developing a derivative of the chemotherapy agent Yondelis as a new payload, which the Singapore venture will first apply to a Claudin 6-targeting ADC it plans to take into a Phase I trial in the US, its chairman, CEO and founder tells Scrip in an interview.

target cancer
Axcynsis finds novel ADC payload in chemotherapy drug trabectedin • Source: Shutterstock

In a shot at repeating Daiichi Sankyo Co., Ltd.’s hugely successful development of deruxtecan as a cytotoxic payload, the holy grail in the design of antibody-drug conjugates (ADCs), Singapore-based Axcynsis Therapeutics is searching for a novel payload within approved chemotherapy drugs.

Its first such try is focusing on a derivative of Johnson & Johnson/

Key Takeaways

  • Singapore-based Axcynsis Therapeutics aims to develop the chemotherapy drug Yondelis (trabectedin) as a payload for antibody-drug conjugates.

  • Axcynsis sees opportunities in rising drug resistance to other payloads such as topoisomerase I inhibitors and tubulin inhibitors including auristatins, according to CEO Bin Zou

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