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Harbinger Health Targets High-Mortality Cancers First With AI-Driven MCED Platform

Harbinger Is Laying Groundwork For Population-Wide Screening With Modular, Methylation-Based Testing

 
• By Shubham Singh

With a projected FDA submission within the next two to three years, Harbinger is prioritizing cancers based on lethality, prevalence, and unmet diagnostic need. Pancreatic and biliary cancers – often diagnosed at late stages and lacking established screening programs – will be among the initial targets.

The Cambridge, MA-based company presented two late-breaking abstracts at the American Association for Cancer Research (AACR) Annual Meeting on 29 April.
Key Takeaways
  • Harbinger’s MCED test integrates a machine-learning model (MLX) with intra-individual methylation analysis (IIX), achieving 99.5% specificity and up to 80.7% positive predictive value for hard-to-detect cancers.

Harbinger Health is advancing a blood-based screening platform initially focused on pancreatic and biliary cancers – two of the deadliest...

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