US Approach To Cell And Gene Therapy Regulations ‘Less Strict’ Than EU

Experts working in the advanced therapy space say the US has less strict criteria for regulatory pathways for cell and gene therapies than the EU, particularly for products in early development.

Anna Koptina, Margareth Jorvid, Shirley Bartido, Sean Russell and Vicki Coutinho at the Advanced Therapies Congress in London, 2025 (Norstella)
Key Takeaways
  • The US regulator has less strict requirements than the EU for supporting cell and gene therapies through development and authorization, two experts say.
  • The US Regenerative Medicine Advanced Therapy designation was also described as having less strict entry criteria than the EU PRIME scheme.
  • Another expert praised the RMAT scheme and said it offered companies with easy access to senior figures at the Food and Drug Administration.

The US Food and Drug Administration takes a “more pragmatic” approach to cell and gene therapy development, which provides companies with a “less stringent pathway” to show that their product...

Bartido’s comments were made as part of a panel discussion at the Advanced Therapies Congress held in London, UK on 19 March. Other panelists, including Medus AB’s head of regulatory...

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