ASH: Gilead/Arcellx Point To Anito-Cel’s Safety, High-Risk Patient Advantages

Multiple myeloma patients in the iMMagine-1 study were less heavily pretreated than in the CARTITUDE-1 trial of Carvykti, but Gilead noted that more patients receiving anito-cel had high-risk features.

Gilead at ASH 2024 (Alaric DeArment/Scrip)

The data that Gilead Sciences subsidiary Kite and Arcellx presented at the American Society of Hematology meeting for anitocabtagene autoleucel (anito-cel) were positive, but the question that remains is whether the apparent safety and tolerability advantage will be sufficient to give the BCMA-directed CAR-T cell therapy a competitive edge over the two players already on the market.

The companies presented data from the Phase II iMMagine-1 study at the ASH annual meeting n San Diego on 9 December, while also laying out plans for a confirmatory Phase...

Key Takeaways
  • Gilead's Kite subsidiary and Arcellx presented positive data at ASH from the Phase II iMMagine-1 trial of anitocabtagene autoleucel, showing a 97% ORR and a...

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