AbbVie Deal Unmasks Promise Of Xilio’s T-Cell Engagers

Masked T-cell engagers are a buzzing field, and AbbVie’s investment has given Xilio some much-needed validation and cash as it goes up against rivals.

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A deal with AbbVie and new preclinical data demonstrating the potential of its masked T-cell engagers have helped revive the fortunes of struggling small-cap biotech Xilio Therapeutics.

The big pharma company will pay $52m upfront to the biotech to develop novel tumor-activated immunotherapies, including masked T-cell engagers (TCEs) with Xilio eligible for a

Key Takeaways
  • 'Masking' technology aims to target TCEs to tumor cells and spare healthy tissue, and Janux's JANX007's has set the pace in the field

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