Vertex Is Firing On All Cylinders But New Drug Launches Remain Challenging

As the architect of the company’s hugely successful business model, Stuart Arbuckle, departs, he hands over a portfolio expanding beyond its cystic fibrosis base, but one that might be slow to build revenues for Casgevy and Journavx.

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Vertex achieved another year of double-digit growth in 2024 thanks to its blockbuster cystic fibrosis (CF) therapies, with the newly approved next-generation drug, Alyftrek, adding to the momentum.

Approved in the US in late December, Alyftrek (vanzacaftor/tezacaftor/deutivacaftor) is a once-daily triple combination cystic fibrosis transmembrane conductance regulator (CFTR) modulator for CF patients six years and older who have at least one F508del

Key Takeaways
  • Vertex achieved double-digit growth in 2024 thanks to its CF portfolio, with the next-generation Alyftrek recently approved

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