Glycomine Funds Phase IIb Rare Disease Trial With $115m Series C

Drug Developer Focused On Glycosylation Disorders

Lead drug GLM101 will move into its first placebo-controlled trial based on positive results in adults and adolescents with PMM2-CDG in an open-label Phase IIa study.

Glycomine raises $115m in venture capital funding (Shutterstock)
Key Takeaways
  • Glycomine raised $115m in series C venture capital to run a Phase IIb clinical trial of GLM101 in phosphomannomutase-2 congenital disorder of glycosylation (PMM2-CDG).
  • Phase IIa results in nine adults and adolescents were encouraging, so enrollment of pediatric patients aged 2-11 is under way.
  • Glycomine is funded beyond the Phase IIb readout expected in mid-2026, giving it time to consider next steps, including whether to seek a partner, go public or raise more venture capital.

Glycomine has spent more than a decade investigating the treatment of glycosylation disorders, starting with phosphomannomutase-2 congenital disorder of glycosylation (PMM2-CDG)

In fact, CEO Steve Axon told Scrip, the series C round announced on 16 April will fund Glycomine beyond the Phase IIb results, keeping the company afloat while it considers whether to engage a partner, go public or pursue additional venture capital for GLM101’s further development

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