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Biogen’s Spinraza Follow-On May Offer Disease-Modifying Potential

 
• By Joseph Haas

Biogen hopes to move directly from Phase I to Phase III with salanersen, a higher-potency therapy that uses the same mechanism of action as Spinraza.

Biogen building
Biogen hopes to move from Phase I to Phase III with SMA candidate • Source: Shutterstock

Biogen is looking to improve the standard of care in spinal muscular atrophy with an aggressive development plan for Spinraza (nusinersen) follow-on salanersen (BIIB115), presenting Phase I data on June 25 at the SMA Research and Clinical Care meeting and outlining its goal to proceed directly from Phase I to a registrational Phase III program.

Key Takeaways
  • Biogen’s Phase I data for Spinraza follow-on salanersen shows ability to restore functioning SMN protein and reduce neurofilament levels, which may provide a disease-modifying effect.

Like Spinraza, salanersen is also an antisense oligonucleotide (ASO) therapy licensed from Ionis that acts to normalize production of the...

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Pipeline Watch: Twelve Approvals And Six Phase III Readouts

Pipeline Watch is a weekly snapshot of selected late-stage clinical trial events and approvals announced by pharmaceutical and biotech companies at medical and industry conferences, in financial and company presentations, and in company releases and statements.