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MetaVia’s ‘Safe’ Obesity Drug Resonates With Analysts, But Not Investors

 
• By Joseph Haas

The biotech reported Phase I multiple-ascending dose data for its obesity drug for the second time in a week, but its safety and tolerability do not offset concerns about relatively unimpressive weight reduction.

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MetaVia shareholders and analysts disagree on prospects for obesity drug DA-1726 (Shutterstock)

MetaVia released new data on 22 April from a Phase I trial of its dual oxyntomodulin analog agonist DA-1726 that it claims might position the drug with a best-in-class safety/tolerability and efficacy profile in obesity, but investors appear unmoved one week after earlier data from the same study caused a more than 50% decrease in the firm’s share price.

Key Takeaways
  • MetaVia reported Phase I data for obesity candidate DA-1726 for the second time in a week, arguing the data show a competitive tolerability profile plus weight loss at four weeks.
  • Despite the update, the biotech’s share price has not recovered from the 56% decline that occurred after an initial readout on 15 April

DA-1726’s novel mechanism of action mimics the effects of GLP-1 and glucagon receptor agonism, but with a cleaner safety and tolerability

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