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ASCO: Carvykti Data Raise Possibility Of Myeloma Cure

 
• By Alaric DeArment

J&J presented data at the American Society of Clinical Oncology meeting showing more than five-year disease- and therapy-free survival, but a myeloma working group will need to define what makes a cure.

(Alaric DeArment)

With new long-term survival data at the recently concluded American Society of Clinical Oncology meeting, Johnson & Johnson and Legend Biotech are less and less shy about using the word “cure” in connection with their CAR-T cell therapy Carvykti (ciltacabtagene autoleucel) for multiple myeloma. But whether the therapy is truly curative will depend on how the International Myeloma Foundation’s International Myeloma Working Group (IMWG) defines the term.

Key Takeaways
  • Data from the CARTITUDE-1 trial showed one-third of patients achieving progression-free status for five years or more, including 12 with no trace of the disease.

J&J presented data from the Phase Ib/II CARTITUDE-1 study in an oral session at the ASCO meeting, which took place...

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