ASCO: DESTINY-Breast09 Strong, But May Need Mature OS Data To Change Practice

AI, Biomarkers Could Help Predict Enhertu Toxicity

Data from AstraZeneca/Daiichi’s breast cancer trial showed positive PFS, but some oncologists are waiting for confirmation of statistically significant OS benefit.

(Alaric DeArment)

AstraZeneca and Daiichi Sankyo’s HER2-targeting antibody-drug conjugate Enhertu (trastuzumab deruxtecan), used in combination with Roche’s HER2-targeting Perjeta (pertuzumab), has potential to change practice in first-line HER2-positive metastatic breast cancer, but some oncologists may want to see more mature overall survival (OS) data before they make that determination.

Key Takeaways
  • AstraZeneca and Daiichi Sankyo presented positive data from the DESTINY-Breast09 trial at ASCO that showed a 44% reduction in the risk of progression or death in HER2-positive metastatic breast cancer in the first line.

The results from the Phase III DESTINY-Breast09 trial, presented June 2 as a late-breaking abstract at the American Society of...

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