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ASH: Pfizer Sees CD70-Targeted MDS Drug As Better For Frailer Patients

 
• By Alaric DeArment

The drug maker presented Phase I data for PF-08046040 at ASH, having designed it to avoid some of the toxicities associated with antibody-drug conjugates.

(Alaric DeArment/Scrip)

An increasingly popular antigen in hematology-oncology as well as solid tumor oncology is CD70, with a number of players developing therapies to target it. But Pfizer believes its PF-08046040, acquired through its purchase of Seagen, could target CD70 in a way more amenable to elderly patients.

The drug maker presented Phase I data in a poster on 7 December at the American Society of Hematology annual meeting for PF-08046040, also known as SEA-CD70, a nonfucosylated CD70-directed monoclonal antibody, combined with Bristol Myers Squibb’s Vidaza

Key Takeaways
  • Pfizer presented Phase I data for an anti-CD70 drug it acquired with Seagen, showing promising efficacy and safety.
  • Unlike most Seagen products, the drug is not an antibody-drug conjugate, but an antibody specially engineered to sidestep ADC-associated toxicities

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