Ocuphire/Opus Merger Creates Public Retinal Gene Therapy Firm

Ocuphire will shift toward gene therapy for inherited retinal degeneration via a merger that will take Opus Genetics public. The firm will also be responsible for one of Ocuphire’s pipeline projects.

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Ocuphire Pharma Inc. and privately held Opus Genetics Inc. announced an all-stock merger on 22 October that will create a publicly traded company focused primarily on gene therapies for inherited retinal degeneration (IRD) disorders, while also fulfilling development of a late-stage Ocuphire asset that it has licensed to Viatris. The merged company will operate under the Opus Genetics name and will have a cash runway into 2026, which should see it through four clinical development inflection points.

Key Takeaways
  • Ocuphire is merging with Opus Genetics with a central focus on the latter’s gene therapy candidates for inherited retinal degeneration disorders.
  • The new company will combine the executive leadership of the two prior firms and finish out development of a Phase III ophthalmic candidate licensed to Viatris

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