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AbbVie On A STEAP Learning Curve In ADCs

 
• By Andrew McConaghie

Investing heavily in antibody-drug conjugates, AbbVie is pioneering a dual STEAP1xPSMA-targeting approach in prostate cancer, as other candidates advance.

AbbVie building
AbbVie continues to manage Humira erosion despite rising biosimilar market share • Source: Alamy

AbbVie wants to become a major player in antibody-drug conjugates (ADCs) and is aiming to expand into prostate cancer with its novel dual-antigen targeting asset, ABBV-969.

This targets the well-known prostate-specific membrane antigen (PSMA) as well as another antigen which is overexpressed in prostate cancer, six-transmembrane epithelial antigen of the prostate 1 (STEAP1), and it carries...

Key Takeaways
  • AbbVie is investing heavily in ADCs, and dual antigen targeting ABBV-969 is one of its most novel assets.
  • The AACR presentation will...

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