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Alector Follows Cassava With An Alzheimer’s Miss

 
• By Elizabeth Cairns

AL002 failed across the board in a mid-stage study, and Alector has trimmed its workforce as it refocuses on its other two assets.

Tumbling blocks
AL002 Fails To Stand Up In Alzheimer's Studies • Source: Shutterstock

Another day, another Alzheimer’s failure. This time it is the turn of Alector, whose AbbVie-partnered anti-TREM2 antibody, AL002, failed in Phase II, and while this is not quite as big a catastrophe as befell Cassava on 25 November, it is bad enough. The company will lay off 17% of its staff as it refocuses on its remaining programs.

Key Takeaways
  • Alector’s anti-TREM2 antibody has failed all primary and secondary analyses in the INVOKE-2 trial in early Alzheimer’s disease.

AL002 failed to differentiate itself from placebo on the INVOKE-2 trial’s primary endpoint of slowing Alzheimer’s clinical progression as measured...

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