Arvinas/Pfizer’s Vepdegestrant Misses Best Case In Phase III

A Phase III trial testing the protein degrader in breast cancer met the primary endpoint and showed an efficacy benefit only in the subgroup of ESR1 mutant patients, not the full population.

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Key Takeaways

A Phase III trial testing Arvinas’ and Pfizer’s estrogen receptor-targeting protein degrader vepdegestrant in breast cancer had mixed results.

While the trial reached the primary efficacy endpoint of PFS in estrogen receptor 1-mutant patients, it missed in the broader population, a profile in line with other oral SERDs.

Investors were disappointed by the update, with Arvinas’ stock losing more than half its value.

Hopes that Arvinas/Pfizer’s estrogen receptor-targeting protein degrader vepdegestrant will show improved efficacy in breast cancer over selective estrogen receptor degraders...

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