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Biogen/UCB’s Lupus Drug Shows Consistent Efficacy Across Endpoints, Over Time

Second Phase III Trial To Begin This Year

 
• By Mandy Jackson

Detailed results for CD40L inhibitor dapirolizumab pegol showed consistent improvements over time with meaningful gains over placebo across all endpoints in its first Phase III study.

Dapirolizumab pegol showed efficacy across various components of SLE disease activity (Shutterstock)

Biogen and UCB may have a differentiated treatment for systemic lupus erythematosus (SLE) based on detailed results from the first Phase III clinical trial of the anti-CD40L antibody dapirolizumab pegol, which consistently separated from placebo with efficacy improving over time across multiple endpoints, including reduced disease activity, less frequent lupus flares and decreased steroid use.

Key Takeaways
  • Biogen and UCB were slated to present detailed positive Phase III PHOENYCS GO results for dapirolizumab pegol (DZP) in systemic lupus erythematosus (SLE) as a late-breaker at ACR.

The companies reported topline results from the 321-patient Phase III PHOENYCS GO trial in September and plan to initiate...

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