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Boehringer’s Three Shots At Schizophrenia Miss The Target

 
• By Andrew McConaghie

Three parallel Phase III studies of iclepertin aiming to improve cognitive function have failed but optimism about other schizophrenia treatments is growing.

Human brain drawn with string
• Source: Alamy

Boehringer Ingelheim’s goal of developing a first-in-class treatment for impaired cognitive function in schizophrenia is over after a trio of Phase III trials of iclepertin failed.

Iclepertin is a glycine transporter 1 (GlyT1) inhibitor that aims to modulate the activity of NMDA receptors, the dysfunction of which is linked to schizophrenia and its cognitive symptoms

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