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Cassava’s Alzheimer’s Drug Fails In First Phase III, Second Pivotal Trial Stopped

SEC Settlement Overhang Remains

 
• By Mandy Jackson

After years of controversy, simufilam did not achieve statistical significance on any endpoints in ReThink-ALZ, so the company ended ReFocus-ALZ and its long-term extension study.

Cassava likely has reached the end of the road with simufilam (Shutterstock)

The long and arduous development path for Cassava Sciences’ simufilam in mild-to-moderate Alzheimer’s disease appears to have come to its end now that the drug failed to deliver statistically significant improvements in cognition and function across any of the primary and secondary endpoints in the Phase III ReThink-ALZ clinical trial.

Based on the trial’s results, the company said on 25 November that it will discontinue a second Phase III study,...

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