China Developers Broadening Global TPD Landscape

Lead Assets Move To Phase III

Multiple Chinese companies are progressing targeted protein degraders, with oncology the dominant indication and two assets already in Phase III for breast cancer.

Ubiquitin is attached to target proteins for the ubiquitination process
(Shutterstock)

“In the following 10 to 20 years, the next R&D peak in small molecules lies in protein degradation; protein degraders will have a market worth at least $100bn,” Liqiang Fu, co-founder and chief technology officer of GluBio Therapeutics, predicted at the recent BioPharma Innovation Week in Shanghai.

Proteolysis targeting chimera (PROTAC) and molecular glues (MGs) are the two main types of protein degrader approaches and globally, in terms of clinical trial progress, multiple PROTACs have

Key Takeaways
  • Oncology is the dominant therapeutic area for protein degraders in both China and globally.
  • Of the 26 drugs developed by Chinese firms that are already in trials, two estrogen receptor-targeted degraders are in Phase III for breast cancer

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Xu Hu

Read more by Xu Hu

Xu is a senior reporter and covers aspects on policy and regulations in China pharma industry within the APAC Pharma news team.

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