In Brief: Strong OS Results For Immutep’s Eftilagimod/Keytruda Combo In Head And Neck Cancer

US FDA Meeting Requested

Australian firm's combo of eftilagimod and Keytruda shows 17.6-month median overall survival in first-line HNSCC patients with low PD-L1, raising hopes for potential accelerated approval.

Cancer Research
Immutep said it will meet with regulators to discuss next steps after strong OS data for combo therapy in 1L HNSCC. (Shutterstock)

Immutep’s combination of its LAG-3 protein/MHC (major histocompatibility complex) Class II agonist eftilagimod alfa and Merck & Co.’s immuno-oncology blockbuster Keytruda (pembrolizumab) has shown impressive median overall survival (OS) of 17.6 months in Cohort B (31 evaluable patients) of the TACTI-003 (KEYNOTE-C34) Phase IIb trial.

The trial is evaluating the combo as a first-line therapy in recurrent/metastatic head and neck squamous cell carcinoma patients with...

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