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In Brief: Tourmaline Reports Positive Topline Phase II Results for Pacibekitug In CKD

Potential Expansion Into Additional Indications

 
• By Sushmita Panda

Based on first positive results for any quarterly IL-6 inhibitor, company plans to initiate Phase III cardiovascular outcomes trial.

Clinical research
Promising topline Phase II results for Tourmaline's quarterly IL-6 inhibitor. (Shutterstock)

Tourmaline Bio’s pacibekitug has shown positive topline results from its ongoing Phase II TRANQUILITY trial, which is evaluating quarterly and monthly subcutaneous dosing of the IL-6 inhibitor in patients with elevated high-sensitivity c-reactive protein (hs-CRP) and chronic kidney disease (CKD).

This is the first time that pacibekitug or any IL-6 inhibitor has been tested in a clinical study with quarterly...

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