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J&J Psoriasis Pill In A Tier Of Its Own After Phase III Win

 
• By Kevin Grogan

The US healthcare giant says that icotrokinra could provide an “industry-leading combination of significant skin clearance with demonstrated tolerability in a once-daily pill" after succeeding in late-stage trials.

Leadership concept, One leader red sphere leads other boxes
• Source: Shutterstock

Johnson & Johnson is preparing regulatory submissions for icotrokinra, its first-in-class oral therapy for psoriasis, after the drug hit its main goals in two Phase III studies.

Key Takeaways

J&J's interleukin-23 receptor blocker has hit in two Phase III psoriasis trials, with regulatory filings planned.

The once-daily pill could provide strong competition to BMS's TYK2 inhibitor Sotyktu and a head-to-head study is ongoing.

Originator Protagonist Therapeutics is now set to receive $165m in milestone payments in the first quarter of 2025.

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