GSK’s linerixibat has hit the endpoints in its Phase III study in cholestatic pruritus in primary biliary cholangitis (PBC), setting it up for approval in this niche indication. But a rival agent, Mirum Pharmaceuticals’ volixibat, posted Phase IIb data in June, and when the full linerixibat data come out they will have to be judged as good as or better than volixibat’s if GSK’s drug is to be successful. However, differences in how the trials’ endpoints will likely mean such a judgement tricky to make.
GSK’s Linerixibat GLISTENs In PBC Itching
But differences in trial design means it is hard to handicap GSK’s product against Mirum’s volixibat.
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