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New Duchenne Results Put Avidity On Course For Filing

 
• By Andrew McConaghie

The potential first-in-class antibody oligonucleotide conjugate could treat a form of the muscle wasting disease, and could be the first of Avidity’s trio of rare disease drugs to gain approval.

(Shutterstock)

Avidity has further strengthened the case for its Duchenne muscular dystrophy candidate, delpacibart zotadirsen, with Phase I/II data showing it boosted levels of the missing dystrophin muscle protein.

Key Takeaways
  • Del zota restored total dystrophin levels to up to 58% of normal and cut by 80% creatine kinase, a key biomarker of muscle damage.

The San Diego, CA-based company is developing delpacibart zotadirsen (del zota) as the lead candidate in its new class of...

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