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Syros’s Hopes Dashed As Tamibarotene Flunks Phase III MDS Trial

 
• By Alaric DeArment

Analysts had hoped a prior negative result in acute myeloid leukemia would not read through to Syros’s Phase III myelodysplastic syndrome study, but SELECT-MDS-1 nevertheless failed too.

white arrow on road pointing towards dead-end brick wall
• Source: Shutterstock

Syros Pharmaceuticals’ tamibarotene has likely reached a dead end as the company announced that the Phase III trial in higher-risk myelodysplastic syndrome (MDS) did not meet its primary endpoint, the second major blow to the firm’s lead candidate in the space of three months.

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