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Vera’s Atacicept Sets A New Efficacy Bar With Phase III Results In IgAN

First-In-Class Drug Exceeds Expectations

 
• By Mandy Jackson

Vera is the first company to report Phase III data for a dual inhibitor of APRIL and BAFF in IgA nephropathy. Atacicept provided a 42% placebo-adjusted reduction in proteinuria.

Vera plans to develop atacicept in other indications, including kidney diseases beyond IgAN (Shutterstock)

Vera Therapeutics reported 36-week results on June 2 from the ORIGIN Phase III clinical trial of its B-cell modulator atacicept in the treatment of immunoglobulin A nephropathy (IgAN) in adults, showing a statistically significant reduction in proteinuria that could support US Food and Drug Administration accelerated approval for the first-in-class drug. The company plans to file its biologics license application (BLA) in the fourth quarter of 2025.

Key Takeaways
  • Vera reported positive 36-week results from its Phase III APRIL/BAFF inhibitor atacicept, a first-in-class drug for IgAN, an increasingly crowded market.

IgAN is an increasingly crowded market with four drugs approved in the US and a fifth...

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