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Zai Lab’s DLL3 ADC Emerges As New Force In ES-SCLC Race

 
• By Dexter Jie Yan

ZL-1310, a DLL3-targeting ADC, has shown a 74% objective response rate in extensive-stage small cell lung cancer after platinum-based chemotherapy, making it a new contender in this setting.

lung cancer
Zai Lab joins the race for best-in-disease treament for small cell lung cancer. • Source: Shutterstock

Zai Lab’s antibody-drug conjugate (ADC) ZL-1310 appears set to disrupt a competitive landscape as a new force in previously treated, extensive-stage small cell lung cancer (ES-SCLC) following promising new results.

While no response duration data are available yet for the DLL3-targeting therapy, ZL-1310 has shown arguably the highest response rate versus its rivals in the dose-escalation stage of

Key Takeaways
  • ZL-1310 has shown arguably the highest response rate versus rivals in previously treated, extensive-stage small cell lung cancer.
  • At data cut-off on 10 October, the objective response rate in 19 patients with at least one post-treatment evaluation was 74%

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