Orphans Cling On To Growth Advantage As Market Share Heads Towards 20%

It might be the beginning of the end for the orphan drugs party but there is still sales growth enjoyment to be had for the sector, whose star performers are now looking increasingly like mainstream drugs.

Rare Diseases
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Key Takeaways

Evaluate’s Orphan Drug Report 2025 finds sales growth advantage is expected to fall to just 1% by the end of the decade

By 2030, these drugs therapies will account for a fifth of all prescription drug sales

The growth advantage long enjoyed by orphan drugs over their non-orphan counterparts looks set to slip to just 1% by the end of the decade, potentially marking the end of an extraordinary run

But the good times are not over yet. Orphans will continue to outpace their mainstream counterparts for a few more years: the category’s 2025-2030 forecast compound annual growth rate (CAGR) tops 10% versus 7.5% for non-orphan prescription drugs, the report shows

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