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CAR-T

Gilead Pipeline Progress Offsets Oncology Sales Slowdown

Sales of the company’s approved cancer therapies were weaker or down, but Trodelvy is likely to see a label expansion and cell therapies are making progress.

Cartesian Maps Out CAR-T Strategy With Simpler Logistics In Mind

The company announced positive Phase IIb data for Descartes-08 in myasthenia gravis, with especially strong efficacy among patients without prior biologic treatment.

Artiva Leverages Unmodified NK Cells To Challenge CAR-T Paradigm

Artiva Biotherapeutics is hoping its NK cell therapy approach, which uses un-engineered cells, will prove effective in both oncologic and autoimmune indications and safe enough to be given in the community setting.

Korea’s First Homegrown CAR-T Therapy On Horizon

Rimqarto is poised to become the first homegrown South Korean CAR-T therapy to gain domestic approval and looks set to provide new local competition to Kymriah.

Immatics Off To Phase III With IMA203 After Positive Melanoma Results

The TCR therapy showed strong efficacy and durability in patients with previously treated melanoma. A Phase III pivotal trial is due to start in December.

Manufacturers Eye Challenges Of Broadening Cell And Gene Therapy Access

With more advanced therapies gaining approval, companies at ARM’s Cell and Gene Meeting on the Mesa considered hurdles to making their products more broadly available and developing them for larger indications.

BMS Inserts Cash Into Prime Medicine’s Gene-Editing Ambitions

An upfront payment of $110m from BMS has come just in time for Prime Medicine, but its real test will be the first Phase I data, expected early next year.

J&J/Legend’s Carvykti Further Cements Myeloma Lead With OS Benefit

New data from CARTITUDE-4 show a survival benefit in patients with lenalidomide-refractory patients as early as the second line, along with Carvykti being studied for frontline use.

2seventy/BMS Halt Abecma Maintenance Trial As Landscape Evolves

The companies said they would stop enrollment in the KarMMa-9 trial of Abecma/lenalidomide due to how the treatment paradigm has shifted since the study started.

ESMO 24: Investors Are Starting To Believe In BioNTech’s Cancer Drugs

The company’s investment in oncology is starting to pay off, with its PD-L1/VEGF inhibitor BNT324 generating particular interest at ESMO.