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Phico Therapeutics Ltd.

 
• By Jeff Dvorin

Phico is developing bacteriophage to deliver antibacterial-based drugs for treating antibiotic-resistant and other bacterial infections. But unlike others using bacteriophage themselves to attack bacteria, Phico's technology employs bacteriophage as the vehicle for delivering a protein that shuts down bacterial activity.

Researchers first began exploring the use of bacteriophage to fight bacterial infection over 80 years ago. Bacteriophage are a well known class of viruses that infect bacteria and destroy them. Although fairly widely used for therapeutic purposes in the 1920s and 1930s, their use tailed off during the middle of the last century. That demise was attributable to a number of factors, including the emergence of a group of antibiotics which still dominates the market, difficulties encountered in the handling and production of bacteriophage, and an incomplete understanding of the biology of bacteriophage.

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