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QSI Pharma AS

 
• By Chris Morrison

QSI Pharma, a Danish start up formed by the Technical University of Denmark and the biotech incubator of Leo Pharma AS, aims to inhibit the formation of deadly biofilms, highly structured and virulent communities of surface colonizing bacteria. QSI aims to discover molecules that interfere with bacterial quorum sensing, a cell-cell signaling process by which bacteria form biofilms when sufficient bacteria have amassed. The company's first target is Pseudomonas aeruginosa, which is responsible for a significant percentage of deaths from many hospital-acquired infections.

Biofilms, highly structured and virulent communities of surface colonizing bacteria, are patient, yet lethal invaders. Through a cell-cell signaling process known as quorum sensing, bacteria that form biofilms wait until sufficient numbers of microorganisms have amassed. Then they attack their host through a coordinated launch of virulence factors including tissue degrading enzymes and other toxic substances. In addition to causing various problems in industrial settings, ranging from corrosion and clogging to food contamination, biofilms cause chronic, stubborn and deadly infections in clinical settings.

[QSI Pharma AS] , a Danish start-up formed by the Technical University of Denmark (DTU) and Leo Incubator, the biotech...

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