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Myriad's Ovarian Cancer Test Proves Its Mettle as Tesaro Companion Dx

 
• By Reed Miller and Lucie Ellis-Taitt

Myriad’s myChoice HRD test has demonstrated its ability to identify more than twice as many ovarian cancer patients who may benefit from treatment with Tesaro’s drug investigational drug niraparib, compared with patient stratification by germline-BRCA testing alone.

Results of the NOVA study show that Myriad Genetics Inc.’s myChoice HRD can identify the ovarian cancer of patients who are most likely to benefit from Tesaro Inc.’s investigational drug niraparib, an inhibitor of poly(adenosine diphosphate [ADP]–ribose) polymerase (PARP-inhibitor). But it remains to be seen if testing with the companion diagnostic will be included in niraparib’s approved indication or not.

Myriad is pursuing US FDA approval for myChoice HRD as a companion diagnostic designation with niraparib in this patient population...

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