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Momentum In Prostate Cancer Therapy Moves Up To First-Line CRPC

 
• By Bridget Silverman

The most recent events in the fast-evolving castration-resistant prostate cancer field illustrate how the major advances in therapy for patients who failed chemotherapy are now spreading to the larger population of CRPC patients receiving first-line therapy for metastatic disease. The upcoming year should see Phase III results from candidates ranging from a kinase inhibitor to an antisense agent.

Now that the treatment landscape has thoroughly transformed for post-chemotherapy metastatic castration-resistant prostate cancer, the fast-evolving space is starting to see shifts in standard care in earlier stages of the disease, beginning with the approval of Johnson & Johnson’s Zytiga for the pre-chemotherapy setting and rapidly progressing with a lineup of clinical trials set to report data in the coming year.

Localized prostate cancer is initially managed through surgical and/or chemical castration with hormonal (androgen deprivation) therapy. Should it advance beyond that, castration- or hormone-resistant prostate cancer has been treated with...

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