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Pharma Adapts Ovarian Cancer Drugs Amid Genomics Revolution

 
• By Emily Hayes

Astra Zeneca hustles on genomic analyses of PARP inhibitor olaparib after drug fails to improve overall survival in a Phase II ovarian cancre trial, which could signify a revival. Meanwhile, Avastin lead investigator defends anti-angiogenesis approach, considering tremendous diversity of the relatively uncommon disease.

New understanding of the genomic diversity of ovarian cancer is already having an effect on drug development in the space, with a possible revival of AstraZeneca LP’s PARP inhibitor olaparib. The company confirms it is looking to tease out the effect of olaparib in a subset of ovarian cancer patients based on BRCA mutations, despite a previous announcement to terminate development in this indication.

Ovarian cancer is a relatively uncommon disease, with 22,000 new cases every year in the U.S., and some experts now see the general diagnosis of ovarian cancer further broken down...

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