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Alzheimer’s Biomarkers For Disease Progression Will Be A Hard Road, Experts Say

 
• By Michael Goodman

A panel of experts discussing challenges in researching disease-progression biomarkers for Alzheimer’s agreed that the heterogeneity and evolving nature of the disease complicate the task and may require large panels of biomarkers – a potentially costly and invasive solution.

The heterogeneity of Alzheimer’s disease goes beyond pathologies of tau and amyloid-beta. It encompasses varying protein domains to be measured, different diagnostic technologies to measure them, and must take into account the evolving nature of the disease. This makes the task of developing biomarkers of disease progression more difficult than in other diseases.

The challenge is complicated by researchers’ incomplete understanding of the pathophysiology of AD and the lack of

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