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On The Threshold Of The Tumor Microenvironment

 
• By Mary Jo Laffler

Threshold Pharmaceuticals’ lead compound from its hypoxia-activated prodrug platform, TH-302, is partnered with Merck KGaA on one Phase III program and in internal development for another Phase III.

Most eyes in oncology are on the immunotherapy space, but despite the intense investment in refocusing the immune system to hit cancer cells, there’s plenty of promise in other approaches, such as targeting the tumor microenvironment.

One of the firms focused on this space is Threshold Pharmaceuticals Inc. with its hypoxia-activated prodrug platform, designed to enable cytotoxic activity in areas of the tumor with low...

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