Reinvigorated Antibiotics Pipeline Could Produce Four NMEs In 2014

With two novel antibiotics approved and two more under review, 2014 is seeing the end of a long lean period for antibacterial R&D, helped by incentives like Qualified Infectious Disease Product designation. But only one candidate, Cubist’s ceftozolane/tazobactam, addresses the urgent need to target resistant Gram-negative bacteria.

Amid growing global concern that existing and proposed incentives for antibiotic development will fall short of meeting public health needs, FDA is poised to approve as many as four novel antibiotics this year – including one candidate for Gram-negative bacterial infections, an especially high priority area.

While the two new molecular entity antibiotics recently approved – Durata Therapeutics Inc.’s second-generation lipoglycopeptide Dalvance (dalbavancin) and

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