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After Pirfenidone: Broad Competition To Bring First Therapy For Underlying Cause Of IPF To Market

In the latest in “The Pink Sheet”’s market snapshot series, InterMune continues to work on getting pirfenidone approved in the U.S., while several companies are developing next-stage therapies for IPF.

Depending upon where a patient lives, idiopathic pulmonary fibrosis is a disease that currently has either very limited or no drug therapy available. A host of big pharma and big biotech firms are competing to bring the first IPF therapy to market in the U.S., but the door is wide open in Europe and Japan, too, where the only approved drug therapy addresses the condition’s symptoms but does not repair its damage or offer the potential for prevention.

The first drug approved for IPF, a progressive scarring of lung tissue of unknown origin, is InterMune Inc.’s pirfenidone, a dual inhibitor of TGF-beta and TGF-alpha synthesis. It is marketed in Europe as Esbriet and in Japan as Pirespa. In the U.S

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