Will New Injectables Sell In An Oral, Mainly Generic Cholesterol World?

PCSK9 inhibitors have come into vogue based on potent LDL-lowering in early studies. But the up-and-coming biologics still face questions about how they will fit in a market dominated largely by proven, oral generics.

Early evidence has built excitement for the investigational class of PCSK9 inhibitors, which have shown robust efficacy at cutting “bad” LDL cholesterol down to size. But positioning and pricing these biologicals in a market largely dominated by cheap and popular oral generics is sure to be a tough balancing act.

In recent months, new PCSK9 inhibitors have quickly captured the imagination of investors, clinicians and the media. Proprotein convertase subtilisin/kexin...

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