Beyond Bapi: Alzheimer’s Pipeline Runs Deep

With the failure of the second of four Janssen-led Phase III trials testing bapineuzumab, partners Janssen and Pfizer have elected to discontinue the bapineuzumab I.V. clinical development program. Nonetheless, the anti-amyloid-beta approach is still alive, as the field turns to early, pre-symptomatic intervention.

Johnson & Johnson and its partner Pfizer Inc. have one shot remaining at the once-promising bapineuzumab program; after discontinuing development of the intravenous formulation after two failed Phase III trials, they still have a Phase II trial ongoing of a subcutaneous formulation of the Alzheimer’s candidate.

That Phase II trial, SUMMIT AD, completed enrollment of approximately 120 North American patients in January. The study, which is...

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