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Beyond Bapi: Alzheimer’s Pipeline Runs Deep

 
• By Michael Goodman

With the failure of the second of four Janssen-led Phase III trials testing bapineuzumab, partners Janssen and Pfizer have elected to discontinue the bapineuzumab I.V. clinical development program. Nonetheless, the anti-amyloid-beta approach is still alive, as the field turns to early, pre-symptomatic intervention.

Johnson & Johnson and its partner Pfizer Inc. have one shot remaining at the once-promising bapineuzumab program; after discontinuing development of the intravenous formulation after two failed Phase III trials, they still have a Phase II trial ongoing of a subcutaneous formulation of the Alzheimer’s candidate.

That Phase II trial, SUMMIT AD, completed enrollment of approximately 120 North American patients in January. The study, which is looking at the drug’s effect on amyloid burden in the...

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Global Pandemic Deal Adopted As 124 Countries Say Yes; US Sits Out

 
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